Melanized Midbrain Dopamine Neurons

The midbrain dopaminergic neurons are characterized by the presence of neurome-lanin. Neuromelanin is distributed mostly in cells that synthesize dopamine, norep-inephrine, but not epinephrine, and it is derived from dopamine, dopaquinone, and their oxidized products as well as catecholamines that are not stored in the vesicles (8). Tetrabenazine and reserpine, drugs that block incorporation of dopamine in the presynaptic vesicles, increase accumulation of neuromelanin and over-expression of

Was this article helpful?

0 0

Post a comment