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Abbreviations: H, hallucinations;N, nausea; OH, orthostatic hypotension; RPF, retroperitoneal or pulmonary fibrosis; S, somnolence.

Source: From Ref. 1. Additional data are collected from published package inserts.

Abbreviations: H, hallucinations;N, nausea; OH, orthostatic hypotension; RPF, retroperitoneal or pulmonary fibrosis; S, somnolence.

Source: From Ref. 1. Additional data are collected from published package inserts.

days after beginning antiemetic agents—domperidone or trimethobenzamide (12). Apomorphine should not be administered with antiemetic serotonin type 3 receptor (5HT3) antagonists, such as ondansetron, granisetron, dolasetron, and palonosetron, because of the risks of severe hypotension and syncope. QT-interval prolongation has been found to be insignificant with doses less than 6 mg.

Dewey et al. (13) demonstrated a 62% improvement in off-state UPDRS scores in subjects with advanced PD, 20 minutes after administering apomorphine in a 2:1 randomized, placebo-controlled trial. Subcutaneously administered apomorphine was also shown to be effective in 30 patients for up to five years of therapy (14).

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