Embryonic Stem Cells

Embryonic stem cells arise from the inner cell mass of the blastocyst, the five-day-old preimplantation embryo. Embryonic stem cells are pluripotent. Embryonic stem cells from mouse, nonhuman primate, and humans (68) have been differentiated into dopaminergic neurons. In current research, human embryonic stem cells typically have been donated as excess material, following in vitro fertilization. When implanted into animal models, these stem cell-derived neurons reinnervate the stria-tum and ameliorate some parkinsonian symptoms (69,70). One concern has been the development of teratomas in the brains of some (71) but not all (72) animals. Recent studies have encouraged differentiation of stem cells into dopaminergic neurons through genetic manipulation and hormonal treatment, such as over-expression of the Nurr-1 transcription factor and exposure to fibroblast growth factor (FGF) and Sonic Hedgehog (73).

Was this article helpful?

0 0
Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

Get My Free Ebook


Post a comment