With the advent of specific dopaminergic agents, the roles of amantadine and anti-cholinergics have taken a back seat. Traditional uses still dominate with amanta-dine used as a mild antiparkinsonian agent, with a well-tolerated side-effect profile and anticholinergics, used to treat tremor predominant PD. In addition, there is evidence that amantadine has efficacy in the modulation of later stage PD motor complications. Careful judgment of use of both of these agents related to their respective side effect profiles remains a concern, particularly with anticholinergics in susceptible elderly patients. In summary, amantadine and anticholinergics are helpful agents in the practicing clinician's arsenal when dealing with particular clinical PD scenarios.
Was this article helpful?