Frontonasal Dysplasia

Median facial clefts with accompanying hypertelorism (fron-tonasal dysplasia) occur in widely varying degrees of severity. Animal models indicate that teratogen-induced distension (resulting from excessive fluid accumulation) of the neural tube shortly after the time of closure can account for some forms of frontonasal dysplasia.32 Also of interest is an animal model resulting from a transgenically induced mutation.71 The rather unusual phenotype results from delayed closure of the anterior neural folds and abnormal separation of the olfactory placodes from the rim of the neural plate.

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