F

FIGURE 1-30A-F. Abnormally close proximity of the nasal placodes and subsequent deficiency in medial nasal prominence development results in the development of a small nose and a long upper lip (from nose to mouth) with a deficient philtrum. Variable degrees of severity of effect in ethanol-exposed mouse fetuses results in phenotypes comparable to those in humans with fetal alcohol syndrome (A,B), cebocephaly (C,D), and premaxillary agenesis (E,F). (From Siebert JR, Cohen MM Jr, Sulik KK. Holoprosencephaly: an overview and atlas of cases. New York: Wiley-Liss, 1990, with permission.)

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