Duplication 4p

Partial trisomy of the short arm of chromosome 4 is a rare abnormality associated with dysmorphic facial features, malformed ears, depressed nasal bridge, short neck, prominent glabella and chin, abnormal genitalia in males, and skeletal anomalies; growth and mental retardation are consistent features. Ophthalmic features include hypertelorism, epicanthus, down-slanting of the palpebral fissures, deeply set eyes, strabismus, blepharophimosis, bushy eyelashes, synophrys, nystagmus, and microphthalmia.64 136 145 163

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