Duplication 10p

Duplication of the short arm of chromosome 10 causes mental and growth retardation. Craniofacial features include dolicho-cephaly, a narrow face, broad cheeks, high forehead, nose with a broad root and bulbous tip, thin lips, cleft lip or palate, fissured tongue, micrognathia, and small chin. Additional manifestations include cardiac and renal anomalies, hypoplastic or cystic lungs, and skeletal anomalies such as camptodactyly, scoliosis, and flexion deformities. Ophthalmic features include hyper-telorism, upward slanting of the palpebral fissures, long, curled eyelashes, and colobomatous microphthalmia.42,135,251,410

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