Deletion 8p

Monosomy of the short arm of chromosome 8 in band 2 is characterized by microcephaly with a narrow head and high forehead, protruding occiput, a flat nasal bridge with a short nose, a short neck, micrognathia, a broad chest with wide-set and hypoplas-

tic nipples, cardiac malformations, and, in males, hypospadias, cryptorchidism, and testicular hypoplasia. Ophthalmic manifestations include hypertelorism, epicanthus, downslanting of the palpebral fissures, strabismus, and nystagmus.27,34,253,279

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