Deletion 10q

Monosomy of the long arm of chromosome 10 causes low birth weight, hypotonia, and microcephaly. Affected individuals may have brachycephaly, a broad and prominent nasal bridge, a small nose with anteverted nostrils, low-set and large ears, a prominent upper lip, and short neck; cleft lip/palate and micrognathia may be evident. Additional features include growth retardation, skeletal anomalies including clinodactyly, syndactyly, an abnormal chest with wide-spaced nipples, and delayed bone age. Ophthalmic features include hypertelorism, up- or downward slanting and narrowing of the palpebral fissures, scant lashes, strabismus, and colobomatous microphthalmia.51,86,201,227,323,347,362,378,395,413

Was this article helpful?

0 0

Post a comment