Nmda Receptors

The NMDA receptors are ionotropic receptors that function as cation channels mediating neuronal depolarization and excitation and play a special role in the induction of synaptic plasticity phenomena. The receptor has recognition sites for the coagonists glutamate and glycine, as well as for other modulatory agents whose binding can alter ion flux through the channel (see Chapter 1; Fig. 1). Agonists at the glutamate and glycine sites activate the NMDA receptor, leading to excitation. Antagonists at these sites have the opposite effect of blocking NMDA-receptor gating and dampening excitation. NMDA-receptor function can also be inhibited by agents that block the ionophore of the channel, that bind to diverse modulatory sites on the channel, or that alter the redox or phosphorylation state of the channel. Drugs that modulate the NMDA receptor in these various ways can have diverse behavioral effects and varying degrees of toxicity. Additional specificity can be determined by the selectivity of certain agents for NMDA receptors composed of different subunit combinations, each with distinct biophysical properties and distributions in the nervous system. Other and, in some cases, more exhaustive reviews of the molecular and behavioral pharmacology of glutamate-receptor systems, which include extensive discussions of structure-activity relationships, are available (2-5).

Natural Detox

Natural Detox

Are you looking for a full total body detox? If so, then you might want to try a 10 day detox or some refer to it as the 2-week detox. A 10-day detox is a full body detox that usually means taking several different steps to reach your total body transformation. It might involve a change in diet, exercise and more.

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