As discussed above, there is widespread agreement that NMDA receptor antagonists inhibit the development of opiate tolerance, sensitization, and physical dependence. However, intriguing evidence
Inhibition of the Development of Opiate Physical Dependence by NMDA Receptor Antagonists
NMDA receptor antagonist
Withdrawal behaviors inhibited
Non-competitive Antagonists MK-801
Rat Rat Rat
Rat (intrathecal) Mouse
CGP 39551 Mouse
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