Nmda Receptors And The Slow Reversal Of Opiate Tolerance And Physical Dependence

As discussed above, there is widespread agreement that NMDA receptor antagonists inhibit the development of opiate tolerance, sensitization, and physical dependence. However, intriguing evidence

Table 5

Inhibition of the Development of Opiate Physical Dependence by NMDA Receptor Antagonists

NMDA receptor antagonist


Withdrawal behaviors inhibited


Non-competitive Antagonists MK-801




Rat Rat Rat

Rat (intrathecal) Mouse

Rat (intrathecal)


Mouse Rat

Rat Rat

Rat (intrathecal)


Rat Rat

Rat Rat

Competitive Antagonists

CGP 39551 Mouse

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