N

NAALASase, see N-Acetylated a-linked-

acidic dipeptidase NAc, see Nucleus accumbens Narp, glutamate receptor binding, 12

NBQX, a -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor binding, 34, 35 cocaine addiction studies, 176 kainate receptor binding, 37, 38 Nerve growth factor (NGF), alcohol effects on levels, 366, 367 Neurexin, glutamate receptor binding, 12 Neuroligin, glutamate receptor binding, 12 NGF, see Nerve growth factor Nicotine, nitric oxide role in conditioned place preference, 233, 234, 29 Nitric oxide (NO), cocaine and methamphetamine behavioral sensitization role, conditioned increases in locomotor activity role, 90, 91 conditioned place preference role,

233, 234, 239 neuronal nitric oxide synthase inhibition studies, knockout mouse studies, 231, 232, 234

7-nitroindazole effects, 230, 233, 234

methamphetamine neurotoxicity, 203, 204,218, 234-236 Nitric oxide synthase (NOS), cocaine addiction studies with inhibitors, 177

isoforms, 40, 229

A-methyl-d-aspartate receptor modulation,

177, 178, 229 neuronal enzyme, inhibitors, 40, 229 knockout mice, 231, 232, 234, 236, 239 opioid effect mediation, antisense mapping of splice variants, 401-403

blockade inhibition of tolerance,

399, 400, 404 reversal of tolerance, 400, 401 therapeutic targeting, 404, 405 NMCQX, receptor specificity, 32 NMDA receptor, see A-Methyl-d-aspartate receptor

NMDX, receptor, specificity, 32 NO, see Nitric oxide NOS, see Nitric oxide synthase NS-102, kainate receptor binding, 38 NS-257, a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor binding, 34 Nucleus accumbens (NAc), acamprosate effects, 410, 411 amphetamine locomotor sensitization, glutamate-dopamine interactions, 186

drug effects on synaptic plasticity, 134-136 glutamate neurotransmission in limbic system, 172-174 motive circuit, neuronal electrophysiology, 146 neurotransmitter release, 147, 148 opioid withdrawal role, 331

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