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a Partial sequence. b as proposed in ref. 3. Source: ref. 3, with permission a Partial sequence. b as proposed in ref. 3. Source: ref. 3, with permission vitro (23). PICK1 also interacts with AMPA receptors (see Section 3.6.). Thus, an extensive network of cytoplasmic proteins exists that serve to anchor, target, and modulate metabotropic glutamate receptors. As described in the following section, many of these proteins play similar roles for the ionotropic glutamate receptors.

The mitogen-activated protein (MAP) kinase ERK2 can be activated by mGluR stimulation, by a G-protein-mediated mechanism (24,25). However, a G-protein-independent mGluRl signaling pathway appears to occur in CA3 pyramidal cells, because a transient activation of a cation conductance follows activation of a Src-family kinase (26).

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