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Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication.

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Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $8.00 per copy, plus US $00.25 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [0-89603-879-3/03 $10.00 + $00.25].

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Library of Congress Cataloging-in-Publication Data

Glutamate and addiction / edited by Barbara H. Herman; coeditors, Jerry Frankenheim...[et al.]. p.;cm.-(Contemporary clinical neuroscience) Includes bibliographical references and index. ISBN 0-89603-879-3 (alk. paper)

1. Substance abuse-Pathophysiology. 2. Glutamic acid-Physiological effect. I. Herman, Barbara H. II. Frankenheim, Jerry. III. Series.

[DNLM: 1. Substance-Related Disorders-physiopathology. 2. Glutamates-pharmacology. 3. Receptors, Glutamates-physiology. WM 270 G567 2002] RC564.G585 2002

616.86-dc21 2002190242


This book is dedicated to our families and collaborators who contributed and supported this effort to characterize the role of glutamatergic systems in addiction disorders and to develop new technologies for the treatment of these brain disorders. This book is also dedicated to Dr. Marian Fischman who died on October 23, 2001 during the final review phase of this book. Dr. Fischman's contributions to the medications development of cocaine and opiate addiction were an outstanding influence in understanding the biology and treatment of addiction disorders. Finally, this book is dedicated to the physicians Lawrence Kelley, md, Jacqueline R. Honig, md, Marc S. Myerson, md, and the countless other valued medical personnel who brought one of us back from a near death experience during its creation.

To Alexandra Samantha Herman, Robert H. Herman, Anita S. Herman

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