Epsp

Output

Presynaptic cell Postsynaptic cell

Output

Presynaptic cell Postsynaptic cell

Presynaptic cell Postsynaptic cell

Fig. 7. Moderate inhibition of excitatory postsynaptic currents by ethanol can result in pronounced inhibition of neuronal signaling. The diagram on the left shows an excitatory glutamatergic synapse under normal conditions. Glutamate released from the presynaptic terminal (in response to its invasion by an action potential) causes an excitatory potential in the postsynaptic cell via activation of AMPA/kainate and NMDA receptors. Because this excitatory potential exceeds the threshold of the postsynaptic cell, it results in the firing of an action potential (shown superimposed on the postsynaptic potential as well as in the axon) and thus propagates the signal to the next synapse(s) in the pathway. The diagram on the right illustrates that a slight inhibition of the postsynaptic potential that drops its amplitude below the threshold can prevent action potential firing and thus prevent the further propagation of the signal.

concentrations have been reported to enhance ethanol inhibition via stimulation of protein kinase C in coexpressed GluRl and GluR3 AMPA receptor subunits (85), whereas in rat cerebellar granule neurons in culture, ethanol inhibition of kainate-evoked increases in intracellular calcium was reversed by stimulation of protein kinase C (47). In homomeric GluR6 kainate receptors however, ethanol inhibition was not altered by activation of protein kinases A and C, calcium/calmodulin-dependent protein kinase II, protein tyrosine kinases, and serine-threonine protein phosphatases (90).

Was this article helpful?

0 0
Natural Detox

Natural Detox

Are you looking for a full total body detox? If so, then you might want to try a 10 day detox or some refer to it as the 2-week detox. A 10-day detox is a full body detox that usually means taking several different steps to reach your total body transformation. It might involve a change in diet, exercise and more.

Get My Free Ebook


Post a comment