Preface vii

Contributors xv

I. Introduction: Physiology and Pharmacology of Glutamate

Philip H. Sheridan, Forrest F. Weight, and Barbara H. Herman Section Editors

1 Molecular Pharmacology and Physiology of Glutamate Receptors 3

Karin Borges and Raymond Dingledine

2 Pharmacology of Glutamate Receptors 23

Jeffrey M. Witkin, Rafal Kaminski, and Michael A. Rogawski

3 Glutamate and Neurotoxicity 51

B. Joy Snider and Dennis W. Choi

4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity 63

Russell M. Sanchez and Frances E. Jensen

5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia 71

Marcus Kaul and Stuart A. Lipton

II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine)

Jerry Frankenheim and Barbara H. Herman, Section Editors

6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned

Increases in Locomotor Activity 83

Agu Pert, Robert M. Post, and Susan R. B. Weiss

7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced

Stereotypy and Behavioral Sensitization 107

Ralph Karler, David K. Thai, and Larry D. Calder

8 Addiction and Glutamate-Dependent Plasticity 127

Marina E. Wolf

9 Glutamate and Dopamine Interactions in the Motive Circuit:

Implications for Craving 143

David A. Baker, Jennifer L. Cornish, and Peter W. Kalivas

10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication 157

John Q. Wang, Limin Mao, and Yuen-Sum Lau xii Contents

11 Glutamate Neurotransmission in the Course of Cocaine

Addiction 171

Luigi Pulvirenti

12 Glutamate and the Self-Administration of

Psychomotor-Stimulant Drugs 183

Paul Vezina and Nobuyoshi Suto

13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and

Apoptosis in the Neurotoxicity of Methamphetamine 201

Jean Lud Cadet

14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative

Processes, and Metabolic Stress 211

Kristan B. Burrows and Bryan K. Yamamoto

15 Nitric Oxide-Dependent Processes in the Action of Psychostimulants 229

Yossef Itzhak, Julio L. Martin, and Syed F. Ali

16 Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral

Toxicity in Mice 243

Rae R. Matsumoto and Buddy Pouw

17 Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence 261

Adam Bisaga and Marian W. Fischman

18 The Role of mGluR5 in the Effects of Cocaine:

Implications for Medication Development 271

Mark P. Epping-Jordan

III. Glutamate and Opiate Drugs (Heroin) of Abuse

Barbara H. Herman and Jerry Frankenheim, Section Editors

19 Role of the Glutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists 281

Jianren Mao

20 The Role of NMDA Receptors in Opiate Tolerance,

Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction 295

Keith A. Trujillo

21 Modification of Conditioned Reward by

N-Methyl-D-aspartate Receptor Antagonists 323

Piotr Popik

22 Morphine Withdrawal as a State of Glutamate Hyperactivity:

The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms 329

Kurt Rasmussen

Contents xiii

IV. Glutamate and Alcohol Abuse and Alcoholism

Forrest F. Weight and Raye Z. Litten, Section Editors

23 Alcohol Actions on Glutamate Receptors 343

Robert W. Peoples

24 Glutamate and Alcohol-Induced Neurotoxicity 357

Fulton T. Crews, Joseph G. Rudolph, and L. Judson Chandler

25 Role of Glutamate in Alcohol Withdrawal Kindling 375

Howard C. Becker and Nicole Redmond

26 Alcohol and Glutamate Neurotransmission in Humans:

Implications for Reward, Dependence, and Treatment 389

John H. Krystal, Ismene L. Petrakis, D. Cyril D'Souza,

Graeme Mason, and Louis Trevisan

27 Mechanism of Action of Acamprosate Focusing on the Glutamatergic System 399

W. Zieglgansberger, G. Rammes, R. Spanagel, W. Danysz, and Ch. Parsons

28 The NMDA/Nitric Oxide Synthase Cascade in Opioid

Analgesia and Tolerance 409

Gavril W. Pasternak and Yuri Kolesnikov

29 Overview of Clinical Studies for Acamprosate 417

Adriaan S. Potgieter

Index 427

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