Glutamate plays a key role in drug dependence and associated behavioral and toxic effects of drugs of abuse. A range of experimental drugs is available to explore further the involvement of glutamate in drug abuse and for the discovery of potential therapeutic candidates. Although these compounds produce a host of common actions and effects, a difference in effects among compounds that appears to derive from the specific molecular targets upon which they act provide a rich diversity for investigatory and development purposes. Both preclinical and clinical findings point to the feasibility of effectively dampening glutamatergic neurotransmission and blocking pathophysiological conditions arising from excessive glutamatergic transmission without major interference with normal neurobehavioral functioning.

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