C

Calcium flux, glutamate neurotoxicity, calcium set point, 54, 55 neuron culture studies, 52 methamphetamine neurotoxicity, 216 mitochondrial effects, 73 p38 activation, 73

striatal neuron expression regulation by metabotropic glutamate receptors, 161-163

CNQX, a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor binding, 34

kainate receptor binding, 37 Cocaine, behavioral sensitization and induced stereotypy mediation by dopamine, glutamate, and y-aminobutyric acid system interactions, intracortical drug effects, agonist-antagonist interactions, 120-122 agonists, 119, 120 antagonists, 118, 119 intrastriatal drug effects, agonist-antagonist interactions,

117,118 antagonists, 115-117 overview, 122-124 study design, 107, 108 systemic antagonist effects, qualitative data, 108-111 quantitative data, 111-115 conditioned increases in locomotor activity, behavioral sensitization, nonassociative versus associative factors, 83, 84 drug addiction relevance, 102 glutamate role, a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor role, 97, 100, 101 long-term potentiation parallels, 101

N-methyl-d-aspartate receptor role,

neuroanatomy, 86, 87, 100, 101 nitric oxide role, 90, 91 neurobiology and dopamine role, 84, 85,101

conditioned place preference, N-methyl-d-aspartate receptor antagonist effects, acquisition, 324, 325 expression, 326 convulsant effects, glutamate release inhibitor treatment, 252

incidence, 248

metabotropic glutamate receptor antagonist blocking, 251, 252 N-methyl-d-aspartate receptor antagonist blocking, allosteric modulators, 250, 251

AMPA/kainate receptor antagonist combination therapy, 251 channel blockers, 250 clinical implications, 255, 256 competitive antagonists, 250 NMDA/glycine antagonists, 248250

dopamine transporter binding, 229 glutamate-dependent synaptic plasticity and addiction, 176-178 glutamate neurotransmission in limbic system, role in abuse, 172-176 lethality, glutamate release inhibitor treatment, 252, 254

A-methyl-d-aspartate receptor antagonist blocking, allosteric modulators, 254 AMPA/kainate receptor antagonist combination therapy, 254 channel blockers, 254 clinical implications, 255, 256 competitive antagonists, 254 NMDA/glycine antagonist pre-treatment and posttreatment, 253

onset, 252, 253 mGluR5 modulation studies, dopamine signaling, 273, 274, 276 learning tasks in mice, 273 locomotor and reinforcing effects,

273, 274 transgenic mice, 272, 273 motive circuit neuroadaptation and glutamate and dopamine interactions, acute drug administration, 149 animal models of addiction, 149 craving implications, 150, 151 repeated drug administration, 150 A-methyl-d-aspartate receptor antagonists, withdrawal and abstinence studies, 266

neural substrates of abuse, 171, 172 overdose adverse effects, 243 sensitization and self-administration, glutamate-dopamine interactions, 188-190, 193, 194

treatment stages for withdrawal, 261 Conditioned place preference (CPP), see also Behavioral sensitization, conditioned reward model, 323, 324 A-methyl-d-aspartate receptor antagonist effects, acquisition, cocaine, 324, 325 morphine, 324, 325 expression, cocaine, 326 morphine, 325, 326 maintenance effects with morphine, 326

nitric oxide role, alcohol, 233, 234 cocaine, 233, 234, 239 nicotine, 233, 234

CPP, conditionedplacepreference, see Conditioned place preference drug psychomotor stimulant studies, behavioral sensitization and induced stereotypy mediation by dopamine, glutamate, and y-aminobutyric acid system interactions, 116, 117, 120-122 CREB, addiction role, 129 CX516, a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor binding, 37 d-Cycloserine, alcohol intoxication blocking, 391, 392 A-methyl-d-aspartate receptor binding, 249,250

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