As always, I would like to thank Huda Akil for her generous support and contributions, intellectual and otherwise, to early portions of the work described in this chapter. I need to acknowledge the hard work and expert technical assistance of several students who contributed to these research efforts, including Ivan Sanchez, Terrance Conner, and Myrna Caballero at the University of Michigan, and Michelle Swadley-Lewellen, Kathleen Warmoth, Karen Watorski, Eric Ruzek, Dawn Albertson, David Peterson, and Ian Mendez at California State University San Marcos. The writing of this review was supported by the National Institute of General Medical Sciences (GM 59833). This chapter is dedicated to the memories of Virginia Fox and Terrance Conner.

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