Animal Models in Head and Neck Cancer

Laboratory of Molecular Pathology Harvard University School of Dental Medicine Boston, Massachusetts 02115

I. Introduction 57

II. History of Experimental Head and Neck Cancer Research 57

A. Animal Models for Head and Neck Cancer

Research: The Value of the Hamster Buccal Pouch Experimental Model for the Study of Oral Cancer 58

III. Genetic Models for Head and Neck Cancer Research 59

A. Targeting Genes to Oral Cavity Epithelia with Promoters 59

B. Other Emerging Genetic Models of Head and Neck Cancer 60

C. Targeted Ablation of Genes in the Oral Cavity 61

D. Future Directions 61

IV. Integrative Human-Based Discoveries and Animal Model Testing for Head and Neck Cancer Research 61 References 61

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