Clinical Patterns In Head And Neck Cancer

What factors determine the TNM stage of a patient's tumor when they present with their head and neck cancers Certainly time can be implicated in accounting for such differences. Patient delay in seeking treatment and their differences in tolerance thresholds for noxious symptoms are clearly important in this respect. Moreover, certain primary sites, such as the endolarynx, tend to be detected earlier due to their anatomy and the subsequent early disruption of function, whereas tumors such as...

Evaluation Of Therapy Of Head And Neck Cancer

The potential role of PET in evaluating tumor response to nonoperative therapies is promising. Many times, artifact produced by chemotherapy or radiotherapy (fibrosis, erythema, edema) may confound the practitioner's ability to evaluate tumor response to therapy either by physical examination or by anatomic imaging. Standard anatomic imaging using CT or MRI has a limited ability to evaluate the effect of radiation or chemotherapy on malignancy. This is most commonly true due to contrast...

Clinical Features

The term leukoplakia (literally white patch) was coined by Schwimmer, a Hungarian pathologist, in the second half of the 19th century 46 . Several studies have, more recently, confirmed the preneoplastic nature of leukoplakia associated with dysplasia, defined its clinical features, and identified clinical and histological features associated with its progression to overt cancer. The definition of leukoplakia, according to the WHO, is the following A predominantly white lesion of the oral...

Genetic Models For Head And Neck Cancer Research

Hpv Promoter

Animal models of head and neck cancer, especially oral cancer, have been used extensively to study chemical carcinogens as elaborated upon in the previous section. However, genetic approaches have lagged considerably until very recently through the employment of gene overexpression in transgenic mice and targeted gene ablation in embryonic stem cells of mice. The advantages of genetic models in mice are several, including the ability to recapitulate human carcinogenesis in large numbers of...

Angiogenesis Basic Mechanisms and Role in Head and Neck Squamous Cell Carcinoma

Lombardi Cancer Center Georgetown University Washington, DC 20007 I. Epidemiology, Pathology, and Biology of Head and Neck Squamous Cell Carcinoma (HNSCC) 81 II. Basic Mechanisms of Angiogenesis 82 B. Mechanisms of Tumor Angiogenesis 83 C. Tumor Angiogenesis The Angiogenic Switch 83 B. Angiogenic Factors in HNSCC 85 IV. Antiangiogenic Therapies in HNSCC 91 V. Conclusions 92 References 92 In the past few years, tumor angiogenesis has been correlated to the progression and metastasis of different...

Info

3 more revealed microinvasion on review. b4 more progressed to CIS 2 had CIS with equivocal invasion. 6. Sternberg, S. (1992). Histology for Pathologists, pp. 451-455. Raven Press, New York. 7. Nasiell, M. (1996). Metaplasia and atypical metaplasia in the bronchial mucosa A histopathological and cytopathological study. Acta Cytol. 10, 421-427. 8. Stiblar-Martincic, D. (1997). Histology of laryngeal mucosa. Acta Otolaryngol. Suppl. (Stockh). 527, 137-141. 9. Fechner, R. E., and Mills, S. E....

Cadher1ns And Intercellular Adhesion

Integrin Cadherin

Oral SCC is formed from stratifed squamous epithelium and as such utilizes the E-cadherin system to maintain cell-cell adhesion. Cadherins are concentrated into junctional plaque structures that can be visualized by electron microscopy as zonula adherens and desmosomes 114,115 . The Cadherin family has been organized into classical Cadherins and desmosomes, but both groups of receptors share highly conserved transmembrane and extracellular regions and interact with a class of cytoplasmic link...