Therapies Targeting the Immune System

The incidence of autoimmune disorders is increased in some MDS populations (Saif et al. 2002). Autologous cy-totoxic T-lymphocytes have been observed to exert an inhibitory effect on MDS myelopoiesis in vitro. The clinical features of subsets of MDS overlap with aplastic anemia (AA) and large granular lymphocyte (LGL) lym-phoproliferative disorders, two diseases thought to be related to dysregulation of the immune system (Barrett et al. 2000). Clinical studies have shown activity of the immunosuppressives antithymocyte globulin and cy-closporine in the treatment of select groups of MDS patients.

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