Epithelial Cell Renewal

Most epithelial cells have a finite life span less than that of the whole organism

Surface epithelia and epithelia of many simple glands belong to the category of continuously renewing cell populations. The rate of cell turnover, i.e., the replacement rate, is characteristic of a specific epithelium. For example, the cells lining the small intestine are renewed every 4 to 6 days in humans. The replacement cells are produced by mitotic activity in the lower portion of the intestinal glands (crypts) (Fig. 4.31). They then migrate

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