Lumen

junctional complex N

apical domain lateral domain intercellula space I

basal dom'ain

include the interstitial cells of Leydig in the testis, the lutein cells of the ovary, the islets of Langerhans in the pancreas, the parenchyma of the adrenal gland, and the anterior lobe of the pituitary gland. Epithelioreticular cells of the thymus also may be included in this category. Epithelioid patterns are also formed by accumulations of connective tissue macrophages in response to certain types of injury and infections, as well as by many tumors derived from epithelium.

Epithelium creates a selective barrier between the external environment and the underlying connective tissue

Covering and lining epithelium forms a sheet-like cellular investment that separates underlying or adjacent connective tissue from the external environment, internal cavities, or fluid connective tissue such as the blood and lymph. Among other roles, this epithelial investment functions as a selective barrier that facilitates or inhibits the passage of specific substances between the exterior (including the body cavities) environment and the underlying connective tissue compartment.

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