Liver Lobules

There are three ways to describe the structure of the liver in terms of a functional unit: the classic lobule, the portal lobule, and the liver acinus. The classic lobule is the traditional way to describe the organization of the liver parenchyma, and it is relatively easy to visualize. It is based on the distribution of the branches of the portal vein and hepatic artery within the organ and the pathway that blood from them follows as it ultimately perfuses the liver cells.

The classic hepatic lobule is a roughly hexagonal mass of tissue

The classic lobule (Fig. 17.3) consists of stacks of anastomosing plates of hepatocytes, one cell thick, separated by the anastomosing system of sinusoids that perfuse the cells with the mixed portal and arterial blood. Each lobule measures about 2.0 X 0.7 mm. At the center of the lobule is a relatively large venule, the terminal hepatic venule (central vein), into which the sinusoids drain. The plates of terminal hepatic venule hepatic i (central vein)

sinusoids /

terminal hepatic venule hepatic i (central vein)

sinusoids /

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