Intracellular Receptors

of steroid hormones, which use intracellular receptors. Binding of the hormone to this receptor causes allosteric transformation of the receptor into a form that binds to DNA. This binding leads to mRNA transcription and production of new proteins that produce hormone-specific responses in the stimulated cell.

function, cells of the GEP system exercise paracrine control of the activity of adjacent epithelial cells by diffusion of peptide secretions through the extracellular spaces.

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