Info

Hemidesmosome

Gap junction (nexus)

Occludins

E-cadherin-

catenin complex

Cadherins (e.g., desmogleins, desmocollins)

Integrins

Integrins

Connexin

Occludins in adjacent cell

E-cadherin-catenin complex in adjacent cell

Desmogleins, desmocollins in adjacent cell

Extracellular matrix protein (e.g., laminin 5, collagen IV)

Connexin in adjacent cell

Actin filaments

Actin filaments a-Actinin, vinculin

Intermediate filaments

Desmoplakins, plakoglobins

Extracellular Actin matrix proteins filaments (e.g., fibronectin)

Vinculin, talin, cx-actinin

Intermediate filaments

Desmoplakin-like proteins, collagen XVII

None

Not known

Seals adjacent cells together to inhibit passage of molecules between them (control of permeability)

Couples the actin cytoskeleton to the plasma membrane at regions of cell-cell adhesion

Couples the intermediate filaments to the plasma membrane at regions of cell-cell adhesion

Anchors the actin cytoskeleton to the extracellular matrix

Anchors the intermediate filaments to the extracellular matrix

Creates a conduit between two adjacent cells for passage of small ions and informational micromolecules

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