Neutrophil phagocytosis, a. Phagocytosis begins with recognition and attachment of foreign material (antigen), mainly by Fc receptors that interact with the Fc region of antibodies bound to the antigen.
b. The antigen is then engulfed by pseudopods of the neutrophil.
c. As the pseudopods come together and fuse, the antigen is internalized. d. Once the phagosome is formed, digestion is initiated by activation of membrane-bounded oxidases of the phagosome, e. Next, both specific and azurophilic granules fuse with the phagosome and exocytosis intonrin
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