Photomicrograph of a mixed bone spicule formed during endochondral bone formation. In this Mallory-Azan-stained section, bone has been deposited on calcified cartilage spicules. In the center of the photomicrograph, the spicules have already grown to create an anastomosing trabecula. The initial trabecula still contains remnants of calcified cartilage, as shown by the light-blue staining of the calcified matrix compared with the dark-blue staining of the bone. In the upper part of the spicule, note a lone osteoclast (arrow) aligned near the surface of the spicule, where remodeling is about to be initiated. x275.
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