Section of mandible developing by the process of intramembranous ossification. This photomicrograph shows a section from a developing mandible, stained with H8E. In this relatively early stage of development, the mandible consists of bone spicules of various sizes and shapes. The bone spicules interconnect with each other and form trabeculae, providing the general shape of the developing bone (no cartilage model is present). The numerous osteoblasts responsible for this growing region of spicules are seen at the surface of the newly deposited bone. The older, calcified portion of spicules contains osteocytes surrounded by bone matrix. In the right portion of the figure, adjacent to the bone spicules, the connective tissue is very cellular and is developing into the early periosteum. x250.
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