Figure 515

Electron micrograph of fibroblasts. The processes of several fibroblasts are shown. The nucleus of one fibroblast is in the upper right of the micrograph. The cytoplasm contains conspicuous profiles of rER. The cisternae of the reticulum are distended, indicating active synthesis. The membranes of the Golgi apparatus (G) are seen in proximity to the rER. Surrounding the cells are collagen fibrils (CF), almost all of which have been cut in cross section and thus appear as small dots at this magnification, x 11,000.

loss of tissue has occurred. TEM studies reveal numerous myofibroblasts in such wound sites, particularly in the granulation tissue of these wounds. Research suggests that these cells may represent modified fibroblasts that have responded to stimuli associated with tissue damage and repair.

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