Figure 423

Molecular structure of focal adhesions. Diagram showing the molecular organization of focal adhesions. On the cytoplasmic side, note the arrangement of different actin-binding proteins. These proteins interact with integrins, the transmembrane proteins, the extracellular domains of which bind to fibronectin.

intermediate filament collagen XVII

intracellular attachment plaque integrin anchoring fibrils

basement membrane intermediate filament collagen XVII

Hemidesmosomes occur in epithelia that require strong, stable adhesion to the connective tissue basement membrane

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