Figure 270

Electron micrograph of apoptotic cells, a. This electron micrograph shows an early stage of apoptosis in a lymphocyte. The nucleus is already fragmented, and the irreversible process of DNA fragmentation is turned on. Note the regions containing condensed heterochromatin adjacent to the nuclear envelope, x 5,200. b. Further fragmentation of DNA. The heterochromatin in one of the nuclear fragments (left) begins to bud outward through the envelope, initiating a new round of

survival factors *TNF •TGF-B
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