Figure 250

Mitotic spindle during normal cell division and in cells lacking centrioles. a. This schematic drawing shows the orientation of the astral bipolar spindle in a normal cell undergoing mitosis. Note the positions of the centrioles and the distribution of the spindle microtubules, b. In a cell that lacks centrioles, mitosis occurs and a mitotic spindle containing only kinetochore microtubules Is formed. However, both poles of the mitotic spindle lack astral microtubules, which position the spindle in proper plane during the mitosis. Such a misoriented spindle is referred to as an anastral bipolar spindle. (Based on Marshall WF, Rosenbaum JL. CurrOpin Cell Biol 2000;112:119-125.)

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