Figure 215

Pathways for delivery of newly synthesized lysosomal enzymes.

Lysosomal enzymes (such as lysosomal hydrolases) are synthesized and glycosylated within the rER. The enzymes then fold in a specific way so that a signal patch is formed, which allows for further modification by the addition of mannose-6-phospate (M-6-P). M-6-P allows the enzyme to be targeted to specific proteins that possess M-6-P receptor activity. M-6-P receptors are present in the frans-Golgi network (TGN) of the Golgi apparatus, where the lysosomal enzymes are sorted and packaged into vesicles later transported to the early or late endosomes and lysosomes.

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