Figure 2115

Electron micrograph of a human Sertoli cell. This electron micrograph shows characteristic crystalloid inclusion bodies of Charcot-Bôttcher in the basal cytoplasm of the Sertoli cell. The basal lamina (BL) is indicated for orientation. x9,000. Inset. This higher magnification shows filaments of the crystalloid. x27,000. (Courtesy of Don F. Cameron.)

The Sertoli cell-to-Sertoli cell junctional complex consists of a structurally unique combination of membrane and cytoplasmic specializations

Sertoli cells are bound to one another by an unusual junctional complex (Fig. 21.17). This complex is characterized, in part, by an exceedingly tight junction (zonula occludens) that includes more than 50 parallel fusion lines in the adjacent membranes. In addition, two cytoplasmic components characterize this unique junctional complex:

• A flattened cisterna of sER lies parallel to the plasma membrane in the region of the junction in each cell.

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