Photomicrograph of centrilobular necrosis in human liver. This photomicrograph shows a routine H&E liver biopsy specimen from an individual with congestive heart failure. Pathologic changes (referred to as ischemic necrosis) are most severe in hepatocytes in zone 3. This zone surrounds the terminal hepatic venule (central vein). This type of necrosis is referred to as centrilobular necrosis. Note the presence of multiple round vacuoles, which indicates extensive lipid accumulation. No noticeable changes are seen in the periphery of the lobule, i.e., zone 1 and much of zone 2. X320.
portal canal zone2
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