Schematic diagram of a plate of hepatocytes interposed between hepatic sinusoids. This diagram shows a one-cell-thick plate of hepatocytes interposed between two sinusoids. If it is assumed that the cell is cuboidal, two sides of each cell (shown) would face hepatic sinusoids, two sides of each cell (shown) would face bile canaliculi, and the additional two sides (not shown) would face bile canaliculi. Note the location and features of a hepatic stellate cell (ito cell) filled with cyto plasmic vacuoles containing vitamin A. The sparse collagen fibers found in the perisinusoidal space (of Disse) are produced by the hepatic stellate cells (Ito cells). In certain pathologic conditions, these cells lose their storage vacuoles and differentiate into myofibroblasts that produce collagen fibers, leading to liver fibrosis. Observe that the stellate sinusoidal macrophage (Kupffer cellj forms an integral part of the sinusoidal lining.
Kupffer cell glycogen space of Disse zonula occludens bile canaliculus mitochondria
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