Figure 137

Schematic diagram of activation of NK cells leading to destruction of a transformed tumor cell by antibody-dependent, cell-mediated cytotoxicity (ADCC). The ADCC reaction involves activation of NK cells by ©the binding of interferon y (IFN-y), the powerful NK cell activator, to its cell surface receptor (IFN-y receptor) and © the bind ing of an antibody- or an antibody- and complement-coated target cell to a NK cell bearing Fr receptors. These reactions induce apoptosis, or lysis of the target cell, usually through the action of tumor-specific antibodies or the action of perforins and fragmentins secreted by activated NK cells.

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