Figure 133

Schematic diagram of the molecular structure of the CD3-TCR complex. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kDa. This molecule is closely associated with the T cell receptor (TCR), which has two polypeptide chains (a and (3). The T cell may be activated following the interaction of the TCR with antigen displayed on the surface of a MHC molecule. This interaction transmits the signals to the interior of the cell through the CD3 molecule. This signal stimulates the T cell to secrete interleukins, which in turn stimulate T cells to divide and differentiate.

Ag-MHC complex binding regions

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