Schematic diagram of cellular interactions in the formation of an atherosclerotic plaque. Endothelial cells express cell adhesion molecules that initiate monocyte migration through the endothelium. Platelet-derived growth factor (PDGF) and other growth factors (blue arrow) released from endothelial cells stimulate migration of the smooth muscle cells from the tunica media to the tunica intima. In the monocyte cell adhesion molecules endothelium tunica intima internal elastic membrane tunica media smooth muscle cells
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