Uptake of fluid and macromolecules during endocytosis depends on three different mechanisms

Some of the endocytotic mechanisms require special proteins during vesicle formation. The best known protein that interacts with the plasma membrane in vesicle formation is clathrin. Therefore, endocytosis can be also be classified as either clathrin dependent or clathrin independent. In general, three mechanisms of endocytosis are recognized in the cell:

• Pinocytosis [Cr„ cell drinking] is the ingestion of fluid and small protein molecules via small vesicles, usually smaller than 150 nm in diameter. Pinocytosis is per

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