Development of the Testis

The testes develop on the posterior wall of the abdomen and later descend into the scrotum

Genetic sex is determined at fertilization by the presence or absence of the Y chromosome. The testes, however, do not form until the seventh week of development. Gonadal sex is determined by the presence of the SRY gene located in the sex-determining region of the short arm of the Y chromosome. A specific DNA-binding protein, called the testis-determining factor (TDF), encoded by the SRY gene, has been found to be directly responsible for testicular development and differentiation.

The testes develop in close association with the urinary system retroperitoneally, on the posterior wall of the abdominal cavity. Testes (like ovaries) are derived from three sources:

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