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Functional Considerations: The Role of Sebum

The role of sebum is not clearly defined. Various investigators have ascribed bacteriostatic, emollient, barrier, and phero-mone functions to sebum. Sebum does appear to play a critical role in the development of acne. The amount of sebum secreted increases significantly at puberty in both males and females. Triglycerides contained in sebum are broken down to fatty acids by bacteria on the skin surface, and the free fatty acids liberated may be an irritant in the formation of acne lesions. On histologic examination, acne is characterized by retention of the sebum in the isthmus of the hair follicle, with variable lymphocytic infiltration. In severe cases, dermal abscesses may form in association with inflamed hair follicles.

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Acne Myths Uncovered

Acne Myths Uncovered

What is acne? Certainly, most of us know what it is, simply because we have had to experience it at one time or another in our lives. But, in case a definition is needed, here is a short one.

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