A variety of inflammatory demyelinating CNS disorders result in the structural hallmarks of the MS lesion, namely, demyelination, inflammation, and variable axonal loss. These disorders represent a broad spectrum of disease with variable clinical course, regional distribution, and pathology, and include the fulminant demyelinating disorders [Marburg variant of acute MS, Balo concentric sclerosis (BCS), and ADEM]; the monosymptomatic idiopathic inflammatory demyelinating disorders (transverse myelitis, isolated optic neuritis or brainstem demyelination); and the recurrent disorders with a restricted topographical distribution [Devic neuromyelitis optica (NMO), and relapsing myelitis] (137).
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