The cause of MS is not known. Considerable indirect evidence points toward an autoimmune etiology. The data in support of an autoimmune cause for MS derive from investigators working worldwide in varied disciplines: genetics, cellular immunology, humoral immunology, and animal models. In addition, the beneficial clinical and imaging responses observed in some MS patients to immunosuppressive agents is consistent with an autoimmune etiology. However, the autoimmune nature of MS remains unproven.

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