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Figure 5 Axial proton density-weighted image of the brain showing a large demyelinating lesion in a patient with multiple sclerosis (A). The corresponding water-suppressed proton magnetic resonance spectra and magnetic resonance spectroscopy imaging are shown in (C) and (D), respectively. For reference, the water-suppressed proton magnetic resonance spectra of a white matter region of the brain from a normal subject is also shown (B). Acute multiple sclerosis lesion reveals increase in choline and lactate resonance intensities and decrease of N-acetyl-aspartate and creatine (C). Abbreviations: NAA, N-acetyl-aspartate; Cho, choline-containing phospholipids; Cr, creatine; Lac, lactate.

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