Does Pathologic Heterogeneity Reflect Pathogenic Heterogeneity In Ms

The demonstration of pathologic heterogeneity in early MS lesions must not be taken as confirmatory evidence for pathogenic heterogeneity among MS patients. This distinction is important as there is a lack of consensus regarding whether lesion heterogeneity can exist within the same patient and is stage-dependent (71), or, in contrast, is patient-dependent and reflects distinct pathogenic subtypes of MS with a dominant effector mechanism of tissue injury operating within a given patient early in the disease (70).

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