Histopathology report

• tumour location: testis/rete/epididymis/cord involvement.

• tumour type - seminomatous/non-seminomatous/sex cord-stromal tumour.

• tumour classification (BTTP or WHO).

• estimate percentage of each component for mixed tumours.

• intratubular, invasive, or both.

- invasion or penetration of tunica albuginea (specify).

- involvement of paratesticular structures.

pT0 no evidence of primary tumour (i.e., scar in testis). pTis intratubular germ cell neoplasia (carcinoma in situ).

pT1 tumour involves testis and epididymis or tunica albuginea, no lymphovascular invasion.

pT2 tumour involves testis and epididymis or tunica vaginalis with lymphovascular invasion.

pT3 tumour invades spermatic cord ± lymphovascular invasion. pT4 tumour invades scrotum ± lymphovascular invasion.

• lymphatic/blood vessel invasion (specify if in testis or paratestis/spermatic cord).

• regional lymph nodes - usually not removed at surgery but retroperitoneal lymph node dissection occasionally performed - usually following orchidectomy and chemo/radio-therapy.

- abdominal, periaortic and pericaval and those along the spermatic veins. pN0 no regional lymph node metastases.

pN1 regional lymph node metastasis < 2 cm but < 5 positive nodes.

pN2 regional lymph node metastasis > 2 cm but < 5 cm, or >5 positive nodes, or extra-

nodal extension.

pN3 regional lymph node metastasis > 5 cm.

• other tissue(s) - involved/uninvolved by tumour.

• results of special studies (immunohistochemistry - alpha-fetoprotein, HCG, PLAP, CAM 5.2, EMA (germ cell tumours), inhibin (sex cord stromal)).

- comments - correlation with other specimens, as appropriate

- correlation with clinical information, as appropriate

- presence/absence of embryonal carcinoma, yolk sac tumour and lymphovascular invasion are prognostically significant.

• resection margin(s), including spermatic cord.

• additional pathologic findings; Leydig cell hyperplasia (correlated with HCG), scarring, the presence of haemosiderin-laden macrophages and intratubular calcification (tumour regression), testicular atrophy, and abnormal testicular development (e.g., dysgenesis).

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